In a significant move to cement American leadership in technology, President Donald J. Trump has launched a major national initiative called the Genesis Mission. The program will use artificial intelligence to try to dramatically speed up scientific research .
An executive order signed on November 24, 2025, charges the Department of Energy with leading the effort. The goal is to unite the vast resources of the federal government, including its national laboratories and supercomputers, with private companies and academic institutions . Officials describe the mission as a historic national effort, comparing its urgency and scale to the World War II-era Manhattan Project .
The mission aims to solve some of the nation's most pressing challenges. It will focus on areas like achieving energy dominance, strengthening national security, and advancing discovery in fields like biotechnology and semiconductors . The Department of Energy Secretary, Chris Wright, said the mission will "unleash the full power of our National Laboratories" to ensure America leads in artificial intelligence .
This initiative arrives as the global competition for AI dominance intensifies. Recent data shows the United States still leads in producing top AI models. However, China is quickly closing the performance gap, and the race for technological supremacy is a key driver of national policy . The White House believes that applying AI to science can reverse a slowdown in progress. Despite growing research budgets, the pace of new discoveries and drug approvals has stalled in recent decades .
The core of the Genesis Mission is the creation of the American Science and Security Platform. This will be an integrated, closed-loop system for research . The platform will connect powerful federal assets, including the world's largest collection of scientific datasets and some of the fastest supercomputers . It is designed to provide AI modeling tools, foundation models, and access to robotic laboratories for AI-directed experiments .
A key part of the strategy involves forming deep partnerships with the technology industry. Just last month, the Department of Energy announced a landmark partnership with NVIDIA and Oracle to build its largest ever AI supercomputer . The system, named Solstice, will feature 100,000 advanced NVIDIA Blackwell GPUs. A second system, Equinox, will also be built at Argonne National Laboratory . Jensen Huang, CEO of NVIDIA, called AI "the most powerful technology of our time" and said this partnership will create an "engine for discovery" .
The Genesis Mission will not only use AI to analyze existing data but also to actively drive experiments. The platform will create AI agents capable of testing new hypotheses and automating complex research workflows . The Department of Energy has been instructed to identify capabilities across its national labs for robotic facilities that can run experiments directed by AI . This could transform research that once took years into work that takes only weeks or months .
The mission has a clear set of initial focus areas. Within 60 days, the Secretary of Energy must identify at least 20 science and technology challenges of national importance . These will span priority domains such as advanced manufacturing, scientific discovery in nuclear fusion, quantum information science, and securing the supply of critical materials . A White House fact sheet also highlighted space exploration as a key area for AI application .
The push to use AI in science comes as the technology becomes deeply embedded in the business world. A recent McKinsey survey found that 88% of organizations now report using AI in at least one business function . Many companies are also beginning to experiment with AI agents, which can plan and execute multi-step tasks autonomously . The Genesis Mission aims to apply this kind of advanced, agentic AI directly to scientific problems .
The federal government is betting that this concentrated effort will produce major economic and security benefits. The White House stated the mission is designed to "multiply the return on taxpayer investment into research and development" . Officials hope it will strengthen America's strategic position by accelerating the development of technologies crucial for energy, defense, and industry .
This initiative is the latest in a series of actions by the Trump administration to promote American AI development. Earlier this year, the President released America's AI Action Plan and signed orders aimed at boosting AI education and reducing regulatory barriers . The administration has also pursued unconventional arrangements with chipmakers, including taking equity stakes in companies like Intel in exchange for export licenses .
The mission also confronts a critical challenge linked to the AI boom: its massive energy demands. Data centers powering AI services are expected to consume a much larger share of U.S. electricity in the coming years . Secretary Wright has said the Genesis Mission will work to "make our electricity grid more efficient and reverse price rises" that have frustrated Americans . Achieving this will be a complex task, as power grids already face strains from severe weather and the rapid expansion of data centers .
The Genesis Mission represents a substantial bet on the power of AI to redefine the very process of discovery. By connecting the nation's top scientific minds, its most powerful computers, and the agility of private industry, the government hopes to open a new chapter of American innovation. The success of this ambitious endeavor will be measured by its ability to deliver tangible breakthroughs that enhance national security, drive economic growth, and solidify the United States' position as the global leader in artificial intelligence .